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Binding of neuroligins to PSD-95.

PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2 receptor) and K+ channels to synapses. In mouse forebrain, PSD-95 bound to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules that interact with beta-neurexins and form intercellular junctions. Neuroligins bind to the third PDZ domain of PSD-95, whereas NMDA2 receptors and K+ channels interact with the first and second PDZ domains. Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins.

Pubmed ID: 9278515


  • Irie M
  • Hata Y
  • Takeuchi M
  • Ichtchenko K
  • Toyoda A
  • Hirao K
  • Takai Y
  • Rosahl TW
  • S├╝dhof TC


Science (New York, N.Y.)

Publication Data

September 5, 1997

Associated Grants

  • Agency: NIMH NIH HHS, Id: R01-MH52804

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • COS Cells
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Cell Adhesion Molecules, Neuronal
  • Cell Line
  • Cell Membrane
  • Cytoplasm
  • Guanylate Kinase
  • Intercellular Junctions
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Mice
  • Molecular Sequence Data
  • Nerve Tissue Proteins
  • Neurons
  • Nucleoside-Phosphate Kinase
  • Potassium Channels
  • Prosencephalon
  • Receptors, N-Methyl-D-Aspartate
  • Recombinant Fusion Proteins
  • Tumor Suppressor Proteins