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Binding of neuroligins to PSD-95.

Science (New York, N.Y.) | Sep 5, 1997

http://www.ncbi.nlm.nih.gov/pubmed/9278515

PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2 receptor) and K+ channels to synapses. In mouse forebrain, PSD-95 bound to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules that interact with beta-neurexins and form intercellular junctions. Neuroligins bind to the third PDZ domain of PSD-95, whereas NMDA2 receptors and K+ channels interact with the first and second PDZ domains. Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins.

Pubmed ID: 9278515 RIS Download

Mesh terms: Amino Acid Sequence | Animals | COS Cells | Calcium-Calmodulin-Dependent Protein Kinases | Cell Adhesion Molecules, Neuronal | Cell Line | Cell Membrane | Cytoplasm | Guanylate Kinase | Intercellular Junctions | Intracellular Signaling Peptides and Proteins | Membrane Proteins | Mice | Molecular Sequence Data | Nerve Tissue Proteins | Neurons | Nucleoside-Phosphate Kinase | Potassium Channels | Prosencephalon | Receptors, N-Methyl-D-Aspartate | Recombinant Fusion Proteins | Tumor Suppressor Proteins

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Associated grants

  • Agency: NIMH NIH HHS, Id: R01-MH52804

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