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Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice.

IL-1alpha and IL-1beta are potent inflammatory cytokines that contribute to a number of normal physiologic processes and to the development of a number of inflammatory diseases. Two IL-1R, the type I and type II receptors, have been identified. This work describes the derivation and characterization of mice deficient in expression of the type I IL-1R (IL-1RI). IL-1RI-deficient mice were viable and fertile, but failed to respond to IL-1 in a variety of assays, including IL-1-induced IL-6 and E-selectin expression and IL-1-induced fever. Similar to IL-1beta-deficient mice, IL-1RI-deficient mice had a reduced acute phase response to turpentine. In contrast, IL-1RI-deficient mice had a reduced delayed-type hypersensitivity response and were highly susceptible to infection by Listeria monocytogenes. These data demonstrate that the IL-1RI is essential for all IL-1-mediated signaling events examined, and that both IL-1alpha and IL-1beta are critical to the animals' response to injury and infection. These data also demonstrate that IL-1 function is not required for normal development or homeostasis.

Pubmed ID: 9278338


  • Labow M
  • Shuster D
  • Zetterstrom M
  • Nunes P
  • Terry R
  • Cullinan EB
  • Bartfai T
  • Solorzano C
  • Moldawer LL
  • Chizzonite R
  • McIntyre KW


Journal of immunology (Baltimore, Md. : 1950)

Publication Data

September 1, 1997

Associated Grants

  • Agency: NICHD NIH HHS, Id: HD07855
  • Agency: NIGMS NIH HHS, Id: R01-GM-40586

Mesh Terms

  • Acute-Phase Reaction
  • Animals
  • Cells, Cultured
  • Disease Susceptibility
  • E-Selectin
  • Female
  • Fever
  • Fibroblasts
  • Gene Targeting
  • Hypersensitivity, Delayed
  • Inflammation
  • Interleukin-1
  • Interleukin-6
  • Listeriosis
  • Male
  • Mice
  • Mice, Knockout
  • Receptors, Interleukin-1
  • Receptors, Interleukin-1 Type I
  • Signal Transduction
  • Turpentine