Maintenance has been completed and SciCrunch services have been restored. We apologize for any inconvenience it may have caused.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice.

IL-1alpha and IL-1beta are potent inflammatory cytokines that contribute to a number of normal physiologic processes and to the development of a number of inflammatory diseases. Two IL-1R, the type I and type II receptors, have been identified. This work describes the derivation and characterization of mice deficient in expression of the type I IL-1R (IL-1RI). IL-1RI-deficient mice were viable and fertile, but failed to respond to IL-1 in a variety of assays, including IL-1-induced IL-6 and E-selectin expression and IL-1-induced fever. Similar to IL-1beta-deficient mice, IL-1RI-deficient mice had a reduced acute phase response to turpentine. In contrast, IL-1RI-deficient mice had a reduced delayed-type hypersensitivity response and were highly susceptible to infection by Listeria monocytogenes. These data demonstrate that the IL-1RI is essential for all IL-1-mediated signaling events examined, and that both IL-1alpha and IL-1beta are critical to the animals' response to injury and infection. These data also demonstrate that IL-1 function is not required for normal development or homeostasis.

Pubmed ID: 9278338

Authors

  • Labow M
  • Shuster D
  • Zetterstrom M
  • Nunes P
  • Terry R
  • Cullinan EB
  • Bartfai T
  • Solorzano C
  • Moldawer LL
  • Chizzonite R
  • McIntyre KW

Journal

Journal of immunology (Baltimore, Md. : 1950)

Publication Data

September 1, 1997

Associated Grants

  • Agency: NICHD NIH HHS, Id: HD07855
  • Agency: NIGMS NIH HHS, Id: R01-GM-40586

Mesh Terms

  • Acute-Phase Reaction
  • Animals
  • Cells, Cultured
  • Disease Susceptibility
  • E-Selectin
  • Female
  • Fever
  • Fibroblasts
  • Gene Targeting
  • Hypersensitivity, Delayed
  • Inflammation
  • Interleukin-1
  • Interleukin-6
  • Listeriosis
  • Male
  • Mice
  • Mice, Knockout
  • Receptors, Interleukin-1
  • Receptors, Interleukin-1 Type I
  • Signal Transduction
  • Turpentine