Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.

Cell | Aug 8, 1997

http://www.ncbi.nlm.nih.gov/pubmed/9267036

We report here the identification of a novel cofactor, ACTR, that directly binds nuclear receptors and stimulates their transcriptional activities in a hormone-dependent fashion. ACTR also recruits two other nuclear factors, CBP and P/CAF, and thus plays a central role in creating a multisubunit coactivator complex. In addition, and unexpectedly, we show that purified ACTR is a potent histone acetyltransferase and appears to define a distinct evolutionary branch to this recently described family. Thus, hormonal activation by nuclear receptors involves the mutual recruitment of at least three classes of histone acetyltransferases that may act cooperatively as an enzymatic unit to reverse the effects of histone deacetylase shown to be part of the nuclear receptor corepressor complex.

Pubmed ID: 9267036 RIS Download

Mesh terms: Acetyltransferases | Amino Acid Sequence | Animals | CREB-Binding Protein | Cell Cycle Proteins | Cloning, Molecular | Histone Acetyltransferases | Humans | Lung Neoplasms | Macromolecular Substances | Mammals | Molecular Sequence Data | Nuclear Proteins | Protein Binding | Receptors, Cytoplasmic and Nuclear | Receptors, Retinoic Acid | Recombinant Proteins | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Trans-Activators | Transcription Factors | Transcription, Genetic | Transcriptional Activation | Transfection | Tumor Cells, Cultured | p300-CBP Transcription Factors

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIGMS NIH HHS, Id: GM26444
  • Agency: NICHD NIH HHS, Id: HD27183

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.