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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.

Nature | Aug 7, 1997

http://www.ncbi.nlm.nih.gov/pubmed/9252186

Nuclear transcription factors of the NF-kappaB/Rel family are inhibited by IkappaB proteins, which inactivate NF-kappaB by trapping it in the cell cytoplasm. Phosphorylation of IkappaBs marks them out for destruction, thereby relieving their inhibitory effect on NF-kappaB. A cytokine-activated protein kinase complex, IKK (for IkappaB kinase), has now been purified that phosphorylates IkappaBs on the sites that trigger their degradation. A component of IKK was molecularly cloned and identified as a serine kinase. IKK turns out to be the long-sought-after protein kinase that mediates the critical regulatory step in NF-kappaB activation.

Pubmed ID: 9252186 RIS Download

Mesh terms: Amino Acid Sequence | Cloning, Molecular | Enzyme Activation | HeLa Cells | Humans | I-kappa B Kinase | Inflammation Mediators | Kinetics | Molecular Sequence Data | NF-kappa B | Phosphoprotein Phosphatases | Phosphorylation | Protein-Serine-Threonine Kinases | Substrate Specificity | Tumor Necrosis Factor-alpha