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An MRI study of the corpus callosum in autism.

OBJECTIVE: The purpose of this study was to examine the size of subregions of the corpus callosum in autistic individuals. METHOD: The areas of three subregions (anterior, body, and posterior) of the corpus callosum were examined on midsagittal magnetic resonance images of 35 autistic subjects whose mean age was 18 years and 36 healthy comparison subjects matched on age and IQ. RESULTS: After controlling for total brain volume, gender, and performance IQ, the authors detected a significantly smaller size of the body and posterior subregions of the corpus callosum in the autistic individuals. CONCLUSIONS: In the context of recent reports of increased brain size in autism, several possible mechanisms are considered in exploring the significance of a smaller relative size of the corpus callosum in autism.

Pubmed ID: 9247388


  • Piven J
  • Bailey J
  • Ranson BJ
  • Arndt S


The American journal of psychiatry

Publication Data

August 15, 1997

Associated Grants

  • Agency: NIMH NIH HHS, Id: MH-01028
  • Agency: NIMH NIH HHS, Id: MH-40856
  • Agency: NIMH NIH HHS, Id: MH-51217

Mesh Terms

  • Adolescent
  • Adult
  • Autistic Disorder
  • Brain
  • Child
  • Corpus Callosum
  • Female
  • Humans
  • Intelligence Tests
  • Magnetic Resonance Imaging
  • Male
  • Neural Pathways
  • Sex Factors