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TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes.

http://www.ncbi.nlm.nih.gov/pubmed/9217007

The growth and differentiation factor transforming growth factor-beta2 (TGFbeta2) is thought to play important roles in multiple developmental processes. Targeted disruption of the TGFbeta2 gene was undertaken to determine its essential role in vivo. TGFbeta2-null mice exhibit perinatal mortality and a wide range of developmental defects for a single gene disruption. These include cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital defects. The developmental processes most commonly involved in the affected tissues include epithelial-mesenchymal interactions, cell growth, extracellular matrix production and tissue remodeling. In addition, many affected tissues have neural crest-derived components and simulate neural crest deficiencies. There is no phenotypic overlap with TGFbeta1- and TGFbeta3-null mice indicating numerous non-compensated functions between the TGFbeta isoforms.

Pubmed ID: 9217007 RIS Download

Mesh terms: Abnormalities, Multiple | Animals | Bone and Bones | Cleft Palate | Craniofacial Abnormalities | Cyanosis | Ear, Inner | Embryonic Induction | Epithelium | Eye Abnormalities | Genes, Homeobox | Heart Defects, Congenital | Mesoderm | Mice | Mice, Inbred C57BL | Mice, Knockout | Phenotype | Transforming Growth Factor beta | Tretinoin | Urogenital Abnormalities

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Associated grants

  • Agency: NIDCD NIH HHS, Id: DC00119
  • Agency: NICHD NIH HHS, Id: HD26471
  • Agency: NHLBI NIH HHS, Id: HL41496
  • Agency: NICHD NIH HHS, Id: R01 HD026471

Comparative Toxicogenomics Database (Data, Disease Annotation)

Mouse Genome Informatics (Data, Gene Annotation)

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