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Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging.

Biological psychiatry | Jul 1, 1997

A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.

Pubmed ID: 9193740 RIS Download

Mesh terms: Adult | Algorithms | Basal Ganglia | Caudate Nucleus | Cohort Studies | Corpus Striatum | Dominance, Cerebral | Female | Globus Pallidus | Humans | Image Processing, Computer-Assisted | Magnetic Resonance Imaging | Obsessive-Compulsive Disorder | Putamen | Reference Values | Trichotillomania