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Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1.

Science (New York, N.Y.) | Jun 13, 1997

http://www.ncbi.nlm.nih.gov/pubmed/9180080

Extracellular levels of the excitatory neurotransmitter glutamate in the nervous system are maintained by transporters that actively remove glutamate from the extracellular space. Homozygous mice deficient in GLT-1, a widely distributed astrocytic glutamate transporter, show lethal spontaneous seizures and increased susceptibility to acute cortical injury. These effects can be attributed to elevated levels of residual glutamate in the brains of these mice.

Pubmed ID: 9180080 RIS Download

Mesh terms: ATP-Binding Cassette Transporters | Amino Acid Transport System X-AG | Animals | Biological Transport | Brain | Brain Injuries | Electroencephalography | Epilepsy | Gene Targeting | Glutamic Acid | Hippocampus | Mice | Mice, Inbred C57BL | Nerve Degeneration | Pyramidal Cells | Synapses | Synaptic Transmission

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