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Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C.

Science (New York, N.Y.) | May 30, 1997

http://www.ncbi.nlm.nih.gov/pubmed/9162005

Members of the myocyte enhancer factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, serum response factor)-box transcription factors bind an A-T-rich DNA sequence associated with muscle-specific genes. The murine MEF2C gene is expressed in heart precursor cells before formation of the linear heart tube. In mice homozygous for a null mutation of MEF2C, the heart tube did not undergo looping morphogenesis, the future right ventricle did not form, and a subset of cardiac muscle genes was not expressed. The absence of the right ventricular region of the mutant heart correlated with down-regulation of the dHAND gene, which encodes a basic helix-loop-helix transcription factor required for cardiac morphogenesis. Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development.

Pubmed ID: 9162005 RIS Download

Mesh terms: Acyltransferases | Animals | Gene Expression Regulation, Developmental | Gene Targeting | Heart | Heart Ventricles | In Situ Hybridization | MEF2 Transcription Factors | Mice | Mice, Inbred C57BL | Morphogenesis | Mutagenesis | Myocardium | Myogenic Regulatory Factors | Stem Cells

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Associated grants

  • Agency: NHLBI NIH HHS, Id: R01 HL053351

Mouse Genome Informatics (Data, Gene Annotation)

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