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Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C.

Members of the myocyte enhancer factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, serum response factor)-box transcription factors bind an A-T-rich DNA sequence associated with muscle-specific genes. The murine MEF2C gene is expressed in heart precursor cells before formation of the linear heart tube. In mice homozygous for a null mutation of MEF2C, the heart tube did not undergo looping morphogenesis, the future right ventricle did not form, and a subset of cardiac muscle genes was not expressed. The absence of the right ventricular region of the mutant heart correlated with down-regulation of the dHAND gene, which encodes a basic helix-loop-helix transcription factor required for cardiac morphogenesis. Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development.

Pubmed ID: 9162005

Authors

  • Lin Q
  • Schwarz J
  • Bucana C
  • Olson EN

Journal

Science (New York, N.Y.)

Publication Data

May 30, 1997

Associated Grants

  • Agency: NHLBI NIH HHS, Id: R01 HL053351

Mesh Terms

  • Acyltransferases
  • Animals
  • Gene Expression Regulation, Developmental
  • Gene Targeting
  • Heart
  • Heart Ventricles
  • In Situ Hybridization
  • MEF2 Transcription Factors
  • Mice
  • Mice, Inbred C57BL
  • Morphogenesis
  • Mutagenesis
  • Myocardium
  • Myogenic Regulatory Factors
  • Stem Cells