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Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.

The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.

Pubmed ID: 9126737

Authors

  • Fazeli A
  • Dickinson SL
  • Hermiston ML
  • Tighe RV
  • Steen RG
  • Small CG
  • Stoeckli ET
  • Keino-Masu K
  • Masu M
  • Rayburn H
  • Simons J
  • Bronson RT
  • Gordon JI
  • Tessier-Lavigne M
  • Weinberg RA

Journal

Nature

Publication Data

April 24, 1997

Associated Grants

None

Mesh Terms

  • Animals
  • Axons
  • Brain
  • Brain Neoplasms
  • Cell Adhesion Molecules
  • Cell Division
  • Chimera
  • Chromosome Mapping
  • Colorectal Neoplasms
  • Gene Targeting
  • Genes, DCC
  • Humans
  • Intestinal Mucosa
  • Intestinal Neoplasms
  • Intestinal Polyps
  • Mice
  • Mice, Inbred C57BL
  • Mutagenesis
  • Nerve Growth Factors
  • Phenotype
  • Receptors, Cell Surface
  • Spinal Cord
  • Tumor Suppressor Proteins