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Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.

Nature | Apr 24, 1997

The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.

Pubmed ID: 9126737 RIS Download

Mesh terms: Animals | Axons | Brain | Brain Neoplasms | Cell Adhesion Molecules | Cell Division | Chimera | Chromosome Mapping | Colorectal Neoplasms | Gene Targeting | Genes, DCC | Humans | Intestinal Mucosa | Intestinal Neoplasms | Intestinal Polyps | Mice | Mice, Inbred C57BL | Mutagenesis | Nerve Growth Factors | Phenotype | Receptors, Cell Surface | Spinal Cord | Tumor Suppressor Proteins

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Associated grants


Mouse Genome Informatics (Data, Gene Annotation)

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