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A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection.

Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the pathological deposition of cholesterol during atherogenesis as a result of receptor-mediated uptake of modified low-density lipoproteins (mLDL). MSR-A can bind an extraordinarily wide range of ligands, including bacterial pathogens, and also mediates cation-independent macrophage adhesion in vitro. Here we show that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in an animal deficient in apolipoprotein E. Macrophages from MSR-A-deficient mice show a marked decrease in mLDL uptake in vitro, whereas mLDL clearance from plasma occurs at a normal rate, indicating that there may be alternative mechanisms for removing mLDL from the circulation. In addition, MSR-A-knockout mice show an increased susceptibility to infection with Listeria monocytogenes or herpes simplex virus type-1, indicating that MSR-A may play a part in host defence against pathogens.

Pubmed ID: 9069289


  • Suzuki H
  • Kurihara Y
  • Takeya M
  • Kamada N
  • Kataoka M
  • Jishage K
  • Ueda O
  • Sakaguchi H
  • Higashi T
  • Suzuki T
  • Takashima Y
  • Kawabe Y
  • Cynshi O
  • Wada Y
  • Honda M
  • Kurihara H
  • Aburatani H
  • Doi T
  • Matsumoto A
  • Azuma S
  • Noda T
  • Toyoda Y
  • Itakura H
  • Yazaki Y
  • Kodama T



Publication Data

March 20, 1997

Associated Grants


Mesh Terms

  • Animals
  • Apolipoproteins E
  • Arteriosclerosis
  • Cell Adhesion
  • Disease Susceptibility
  • Gene Targeting
  • Herpes Simplex
  • Lipoproteins, LDL
  • Listeriosis
  • Liver
  • Macrophages, Peritoneal
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Receptors, Immunologic
  • Receptors, Scavenger
  • Scavenger Receptors, Class A
  • Spleen