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Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function.

Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.

Pubmed ID: 8999800

Authors

  • Mittrücker HW
  • Matsuyama T
  • Grossman A
  • Kündig TM
  • Potter J
  • Shahinian A
  • Wakeham A
  • Patterson B
  • Ohashi PS
  • Mak TW

Journal

Science (New York, N.Y.)

Publication Data

January 24, 1997

Associated Grants

None

Mesh Terms

  • Animals
  • Antigen Presentation
  • B-Lymphocytes
  • Bone Marrow Cells
  • Cytotoxicity, Immunologic
  • DNA-Binding Proteins
  • Female
  • Gene Targeting
  • Graft vs Host Reaction
  • Immunization
  • Immunoglobulins
  • Interferon Regulatory Factors
  • Lymphatic Diseases
  • Lymphocyte Activation
  • Lymphocyte Subsets
  • Lymphoid Tissue
  • Male
  • Mast-Cell Sarcoma
  • Mice
  • Mice, Inbred C57BL
  • Mice, SCID
  • Neoplasm Transplantation
  • T-Lymphocytes
  • T-Lymphocytes, Cytotoxic
  • Transcription Factors