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Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function.

Science (New York, N.Y.) | Jan 24, 1997

http://www.ncbi.nlm.nih.gov/pubmed/8999800

Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.

Pubmed ID: 8999800 RIS Download

Mesh terms: Animals | Antigen Presentation | B-Lymphocytes | Bone Marrow Cells | Cytotoxicity, Immunologic | DNA-Binding Proteins | Female | Gene Targeting | Graft vs Host Reaction | Immunization | Immunoglobulins | Interferon Regulatory Factors | Lymphatic Diseases | Lymphocyte Activation | Lymphocyte Subsets | Lymphoid Tissue | Male | Mast-Cell Sarcoma | Mice | Mice, Inbred C57BL | Mice, SCID | Neoplasm Transplantation | T-Lymphocytes | T-Lymphocytes, Cytotoxic | Transcription Factors

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