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Subregion- and cell type-restricted gene knockout in mouse brain.

Cell | Dec 27, 1996

http://www.ncbi.nlm.nih.gov/pubmed/8980237

Using the phage P1-derived Cre/loxP recombination system, we have developed a method to create mice in which the deletion (knockout) of virtually any gene of interest is restricted to a subregion or a specific cell type in the brain such as the pyramidal cells of the hippocampal CA1 region. The Cre/loxP recombination-based gene deletion appears to require a certain level of Cre protein expression. The brain subregional restricted gene knockout should allow a more precise analysis of the impact of a gene mutation on animal behaviors.

Pubmed ID: 8980237 RIS Download

Mesh terms: Animals | Calcium-Calmodulin-Dependent Protein Kinases | Gene Expression | Gene Expression Regulation | Genetic Engineering | Gestational Age | Hippocampus | Integrases | Mice | Mice, Knockout | Mice, Transgenic | Promoter Regions, Genetic | RNA, Messenger | Recombination, Genetic | Sequence Deletion | Viral Proteins

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