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Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system.

Cell | Dec 13, 1996

http://www.ncbi.nlm.nih.gov/pubmed/8978605

During nervous system development, spinal commissural axons project toward floor plate cells and trochlear motor axons extend away from these cells. Netrin-1, a diffusible protein made by floor plate cells, can attract spinal commissural axons and repel trochlear axons in vitro, but its role in vivo is unknown. Netrin-1 deficient mice exhibit defects in spinal commissural axon projections that are consistent with netrin-1 guiding these axons. Defects in several forebrain commissures are also observed, suggesting additional guidance roles for netrin-1. Trochlear axon projections are largely normal, predicting the existence of additional cues for these axons, and evidence is provided for a distinct trochlear axon chemorepellent produced by floor plate cells. These results establish netrin-1 as a guidance cue that likely collaborates with other diffusible cues to guide axons in vivo.

Pubmed ID: 8978605 RIS Download

Mesh terms: Alleles | Animals | Axons | Blotting, Southern | Gene Expression Regulation, Developmental | Homozygote | Immunohistochemistry | Mice | Mice, Mutant Strains | Motor Neurons | Mutation | Nerve Growth Factors | Pons | Spinal Cord | Trochlear Nerve | Tumor Suppressor Proteins | Vertebrates

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Mouse Genome Informatics (Data, Gene Annotation)

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