We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Visualizing an olfactory sensory map.

Cell | Nov 15, 1996

We have developed a genetic approach to visualize axons from olfactory sensory neurons expressing a given odorant receptor, as they project to the olfactory bulb. Neurons expressing a specific receptor project to only two topographically fixed loci among the 1800 glomeruli in the mouse olfactory bulb. Our data provide direct support for a model in which a topographic map of receptor activation encodes odor quality in the olfactory bulb. Receptor swap experiments suggest that the olfactory receptor plays an instructive role in the guidance process but cannot be the sole determinant in the establishment of this map. This genetic approach may be more broadly applied to visualize the development and plasticity of projections in the mammalian nervous system.

Pubmed ID: 8929536 RIS Download

Mesh terms: Animals | Axons | Biomarkers | Brain Mapping | In Situ Hybridization | Lac Operon | Mice | Mutagenesis, Site-Directed | Neuronal Plasticity | Olfactory Bulb | Olfactory Receptor Neurons | RNA, Messenger | Receptors, Odorant | Recombinant Fusion Proteins | Smell | Turbinates | tau Proteins

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIMH NIH HHS, Id: 5 P50 MH 50733
  • Agency: NCI NIH HHS, Id: 5 PO1 CA23767

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.