Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity.

Cell | Nov 15, 1996

http://www.ncbi.nlm.nih.gov/pubmed/8929535

Antibodies that block Sonic Hedgehog (SHH) signaling have been used to show that SHH activity is required for the induction of floor plate differentiation by the notochord and independently for the induction of motor neurons by both the notochord and midline neural cells. Motor neuron generation depends on two critical periods of SHH signaling: an early period during which naive neural plate cells are converted into ventralized progenitors and a late period that extends well into S phase of the final progenitor cell division, during which SHH drives the differentiation of ventralized progenitors into motor neurons. The ambient SHH concentration during the late period determines whether ventralized progenitors differentiate into motor neurons or interneurons, thus defining the pattern of neuronal cell types generated in the neural tube.

Pubmed ID: 8929535 RIS Download

Mesh terms: Animals | Body Patterning | Cell Differentiation | Cell Division | Central Nervous System | Chick Embryo | Embryonic Induction | Hedgehog Proteins | Interneurons | Models, Biological | Motor Neurons | Notochord | Proteins | Stem Cells | Time Factors | Trans-Activators

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.