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Inhibition of E2F-mediated transcription by p202.

Many of the antimicrobial, immunomodulatory and cell growth inhibitory activities of the interferons are mediated by interferon-inducible proteins. Earlier we characterized an interferon-inducible murine protein, p202, whose expression in transfected cells inhibits cell proliferation and which can form a complex with retinoblastoma protein (pRb). Here we report that in transfected cells expression of p202 inhibits E2F-stimulated transcription of a reporter gene and of endogenous genes. Inhibition of the transcriptional activity of E2F by p202 does not depend on fully functional pRb and is correlated with inhibition of the sequence-specific DNA binding of E2F. p202 interacts with the transcription factor E2F (E2F-1/DP-1) in vitro and in vivo. Inhibition of E2F activity by p202 may contribute to growth inhibition by the interferons.

Pubmed ID: 8896460


  • Choubey D
  • Li SJ
  • Datta B
  • Gutterman JU
  • Lengyel P


The EMBO journal

Publication Data

October 15, 1996

Associated Grants

  • Agency: NIAID NIH HHS, Id: R37-AI12320

Mesh Terms

  • Animals
  • Carrier Proteins
  • Cell Cycle Proteins
  • Cell Division
  • DNA
  • DNA-Binding Proteins
  • E2F Transcription Factors
  • E2F1 Transcription Factor
  • Electrophoresis, Polyacrylamide Gel
  • Female
  • Genes, Reporter
  • HeLa Cells
  • Humans
  • Interferons
  • Intracellular Signaling Peptides and Proteins
  • Mice
  • Nuclear Proteins
  • Phosphoproteins
  • Retinoblastoma-Binding Protein 1
  • Transcription Factor DP1
  • Transcription Factors
  • Transcription, Genetic
  • Tumor Cells, Cultured