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Inhibition of E2F-mediated transcription by p202.

The EMBO journal | Oct 15, 1996

http://www.ncbi.nlm.nih.gov/pubmed/8896460

Many of the antimicrobial, immunomodulatory and cell growth inhibitory activities of the interferons are mediated by interferon-inducible proteins. Earlier we characterized an interferon-inducible murine protein, p202, whose expression in transfected cells inhibits cell proliferation and which can form a complex with retinoblastoma protein (pRb). Here we report that in transfected cells expression of p202 inhibits E2F-stimulated transcription of a reporter gene and of endogenous genes. Inhibition of the transcriptional activity of E2F by p202 does not depend on fully functional pRb and is correlated with inhibition of the sequence-specific DNA binding of E2F. p202 interacts with the transcription factor E2F (E2F-1/DP-1) in vitro and in vivo. Inhibition of E2F activity by p202 may contribute to growth inhibition by the interferons.

Pubmed ID: 8896460 RIS Download

Mesh terms: Animals | Carrier Proteins | Cell Cycle Proteins | Cell Division | DNA | DNA-Binding Proteins | E2F Transcription Factors | E2F1 Transcription Factor | Electrophoresis, Polyacrylamide Gel | Female | Genes, Reporter | HeLa Cells | Humans | Interferons | Intracellular Signaling Peptides and Proteins | Mice | Nuclear Proteins | Phosphoproteins | Retinoblastoma-Binding Protein 1 | Transcription Factor DP1 | Transcription Factors | Transcription, Genetic | Tumor Cells, Cultured

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