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TRAF6 is a signal transducer for interleukin-1.

Many cytokines signal through different cell-surface receptors to activate the transcription factor NF-kappaB. Members of the TRAF protein family have been implicated in the activation of NF-kappaB by the tumour-necrosis factor (TNF)-receptor superfamily. Here we report the identification of a new TRAF family member, designated TRAF6. When overexpressed in human 293 cells, TRAF6 activates NF-kappaB. A dominant-negative mutant of TRAF6 inhibits NF-kappaB activation signalled by interleukin-1 (IL-1) but not by TNF. IL-1 treatment of 293 cells induces the association of TRAF6 with IRAK, a serine/threonine kinase that is rapidly recruited to the IL-1 receptor after IL-1 induction. These findings indicate that TRAF proteins may function as signal transducers for distinct receptor families and that TRAF6 participates in IL-1 signalling.

Pubmed ID: 8837778

Authors

  • Cao Z
  • Xiong J
  • Takeuchi M
  • Kurama T
  • Goeddel DV

Journal

Nature

Publication Data

October 3, 1996

Associated Grants

None

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Carrier Proteins
  • Cell Line
  • Humans
  • Interleukin-1
  • Interleukin-1 Receptor-Associated Kinases
  • Molecular Sequence Data
  • NF-kappa B
  • Protein Kinases
  • Proteins
  • Sequence Deletion
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • TNF Receptor-Associated Factor 6
  • Transfection