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Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry.

Patients suffering from schizophrenia display subtle cognitive abnormalities that may reflect a difficulty in rapidly coordinating the steps that occur in a variety of mental activities. Working interactively with the prefrontal cortex, the cerebellum may play a role in coordinating both motor and cognitive performance. This positron-emission tomography study suggests the presence of a prefrontal-thalamic-cerebellar network that is activated when normal subjects recall complex narrative material, but is dysfunctional in schizophrenic patients when they perform the same task. These results support a role for the cerebellum in cognitive functions and suggest that patients with schizophrenia may suffer from a "cognitive dysmetria" due to dysfunctional prefrontal-thalamic-cerebellar circuitry.

Pubmed ID: 8790444 RIS Download

Mesh terms: Adult | Cerebellum | Cognition Disorders | Female | Humans | Magnetic Resonance Imaging | Male | Memory | Prefrontal Cortex | Radiography | Schizophrenia | Thalamus | Tomography, Emission-Computed

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Associated grants

  • Agency: NIMH NIH HHS, Id: MH31593
  • Agency: NIMH NIH HHS, Id: MH40856
  • Agency: NIMH NIH HHS, Id: MHCRC43271

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