• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

KAP-1, a novel corepressor for the highly conserved KRAB repression domain.

The KRAB repression domain is one of the most widely distributed transcriptional effector domains yet identified, but its mechanism of repression is unknown. We have cloned a corepressor, KAP-1, which associates with the KRAB domain but not with KRAB mutants that have lost repression activity. KAP-1 can enhance KRAB-mediated repression and is a repressor when directly tethered to DNA. KAP-1 contains a RING finger, B boxes, and a PHD finger; the RING-B1-B2 structure is required for KRAB binding and corepression. We propose that KAP-1 may be a universal corepressor for the large family of KRAB domain-containing transcription factors.

Pubmed ID: 8769649

Authors

  • Friedman JR
  • Fredericks WJ
  • Jensen DE
  • Speicher DW
  • Huang XP
  • Neilson EG
  • Rauscher FJ

Journal

Genes & development

Publication Data

August 15, 1996

Associated Grants

  • Agency: NCI NIH HHS, Id: CA09171
  • Agency: NIDDK NIH HHS, Id: DK45191
  • Agency: NIDDK NIH HHS, Id: DK49210

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Cattle
  • Cloning, Molecular
  • Consensus Sequence
  • DNA-Binding Proteins
  • Deoxyribonucleoproteins
  • Gene Expression Regulation
  • Macromolecular Substances
  • Nuclear Proteins
  • Paired Box Transcription Factors
  • Protein Binding
  • Repressor Proteins
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Transcription Factors
  • Zinc Fingers