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KAP-1, a novel corepressor for the highly conserved KRAB repression domain.

The KRAB repression domain is one of the most widely distributed transcriptional effector domains yet identified, but its mechanism of repression is unknown. We have cloned a corepressor, KAP-1, which associates with the KRAB domain but not with KRAB mutants that have lost repression activity. KAP-1 can enhance KRAB-mediated repression and is a repressor when directly tethered to DNA. KAP-1 contains a RING finger, B boxes, and a PHD finger; the RING-B1-B2 structure is required for KRAB binding and corepression. We propose that KAP-1 may be a universal corepressor for the large family of KRAB domain-containing transcription factors.

Pubmed ID: 8769649


  • Friedman JR
  • Fredericks WJ
  • Jensen DE
  • Speicher DW
  • Huang XP
  • Neilson EG
  • Rauscher FJ


Genes & development

Publication Data

August 15, 1996

Associated Grants

  • Agency: NCI NIH HHS, Id: CA09171
  • Agency: NIDDK NIH HHS, Id: DK45191
  • Agency: NIDDK NIH HHS, Id: DK49210

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Cattle
  • Cloning, Molecular
  • Consensus Sequence
  • DNA-Binding Proteins
  • Deoxyribonucleoproteins
  • Gene Expression Regulation
  • Macromolecular Substances
  • Nuclear Proteins
  • Paired Box Transcription Factors
  • Protein Binding
  • Repressor Proteins
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Transcription Factors
  • Zinc Fingers