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KAP-1, a novel corepressor for the highly conserved KRAB repression domain.

Genes & development | Aug 15, 1996

The KRAB repression domain is one of the most widely distributed transcriptional effector domains yet identified, but its mechanism of repression is unknown. We have cloned a corepressor, KAP-1, which associates with the KRAB domain but not with KRAB mutants that have lost repression activity. KAP-1 can enhance KRAB-mediated repression and is a repressor when directly tethered to DNA. KAP-1 contains a RING finger, B boxes, and a PHD finger; the RING-B1-B2 structure is required for KRAB binding and corepression. We propose that KAP-1 may be a universal corepressor for the large family of KRAB domain-containing transcription factors.

Pubmed ID: 8769649 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Cattle | Cloning, Molecular | Consensus Sequence | DNA-Binding Proteins | Deoxyribonucleoproteins | Gene Expression Regulation | Macromolecular Substances | Nuclear Proteins | PAX3 Transcription Factor | Paired Box Transcription Factors | Protein Binding | Repressor Proteins | Sequence Alignment | Sequence Homology, Amino Acid | Transcription Factors | Zinc Fingers

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Associated grants

  • Agency: NCI NIH HHS, Id: CA09171
  • Agency: NIDDK NIH HHS, Id: DK45191
  • Agency: NIDDK NIH HHS, Id: DK49210

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