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I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

Tumor necrosis factor (TNF) receptor-associated factor (TRAF) proteins associate with and transduce signals from TNF receptor 2, CD40, and presumably other members of the TNF receptor superfamily. TRAF2 is required for CD40- and TNF-mediated activation of the transcription factor NF-kappa B. Here we describe the isolation and characterization of a novel TRAF-interacting protein, I-TRAF, that binds to the conserved TRAF-C domain of the three known TRAFs. Overexpression of I-TRAF inhibits TRAF2-mediated NF-kappa B activation signaled by CD40 and both TNF receptors. Thus, I-TRAF appears as a natural regulator of TRAF function that may act by maintaining TRAFs in a latent state.

Pubmed ID: 8710854


  • Rothe M
  • Xiong J
  • Shu HB
  • Williamson K
  • Goddard A
  • Goeddel DV


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

August 6, 1996

Associated Grants


Mesh Terms

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Sequence
  • Animals
  • Antigens, CD
  • Bacterial Proteins
  • Binding Sites
  • Carrier Proteins
  • Cloning, Molecular
  • Humans
  • Macromolecular Substances
  • Mice
  • Molecular Sequence Data
  • NF-kappa B
  • Peptides
  • Protein Binding
  • Proteins
  • Receptors, Tumor Necrosis Factor
  • Receptors, Tumor Necrosis Factor, Type II
  • Signal Transduction
  • TNF Receptor-Associated Factor 2
  • X-Linked Inhibitor of Apoptosis Protein