I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.
Tumor necrosis factor (TNF) receptor-associated factor (TRAF) proteins associate with and transduce signals from TNF receptor 2, CD40, and presumably other members of the TNF receptor superfamily. TRAF2 is required for CD40- and TNF-mediated activation of the transcription factor NF-kappa B. Here we describe the isolation and characterization of a novel TRAF-interacting protein, I-TRAF, that binds to the conserved TRAF-C domain of the three known TRAFs. Overexpression of I-TRAF inhibits TRAF2-mediated NF-kappa B activation signaled by CD40 and both TNF receptors. Thus, I-TRAF appears as a natural regulator of TRAF function that may act by maintaining TRAFs in a latent state.
Pubmed ID: 8710854 RIS Download
Adaptor Proteins, Signal Transducing | Amino Acid Sequence | Animals | Antigens, CD | Bacterial Proteins | Binding Sites | Carrier Proteins | Cloning, Molecular | Humans | Macromolecular Substances | Mice | Molecular Sequence Data | NF-kappa B | Peptides | Protein Binding | Proteins | Receptors, Tumor Necrosis Factor | Receptors, Tumor Necrosis Factor, Type II | Signal Transduction | TNF Receptor-Associated Factor 2 | X-Linked Inhibitor of Apoptosis Protein