Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.

Cell | Jul 26, 1996

http://www.ncbi.nlm.nih.gov/pubmed/8706131

We have identified the yeast and human homologs of the SKP1 gene as a suppressor of cdc4 mutants and as a cyclin F-binding protein. Skp1p indirectly binds cyclin A/Cdk2 through Skp2p, and directly binds Skp2p, cyclin F, and Cdc4p through a novel structural motif called the F-box. SKP1 is required for ubiquitin-mediated proteolysis of Cin2p, Clb5p, and the Cdk inhibitor Sic1p, and provides a link between these molecules and the proteolysis machinery. A large number of proteins contain the F-box motif and are thereby implicated in the ubiquitin pathway. Different skp1 mutants arrest cells in either G1 or G2, suggesting a connection between regulation of proteolysis in different stages of the cycle.

Pubmed ID: 8706131 RIS Download

Mesh terms: Amino Acid Sequence | Anaphase-Promoting Complex-Cyclosome | Base Sequence | Binding Sites | Cell Cycle | Cell Cycle Proteins | Cyclins | F-Box Proteins | Fungal Proteins | G1 Phase | G2 Phase | Gene Dosage | Gene Expression | Humans | Ligases | Mitosis | Molecular Sequence Data | Molecular Structure | Mutation | Protein Structure, Tertiary | Proteins | S Phase | S-Phase Kinase-Associated Proteins | Saccharomyces cerevisiae Proteins | Ubiquitin-Protein Ligase Complexes | Ubiquitin-Protein Ligases | Ubiquitins | Yeasts

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.