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A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.

The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A. Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase.

Pubmed ID: 8684459


  • Yang XJ
  • Ogryzko VV
  • Nishikawa J
  • Howard BH
  • Nakatani Y



Publication Data

July 25, 1996

Associated Grants


Mesh Terms

  • Acetyltransferases
  • Adenovirus E1A Proteins
  • Amino Acid Sequence
  • Binding, Competitive
  • Cell Cycle
  • Cell Cycle Proteins
  • Cloning, Molecular
  • Escherichia coli
  • HeLa Cells
  • Histone Acetyltransferases
  • Humans
  • Molecular Sequence Data
  • Nuclear Proteins
  • Protein Binding
  • Recombinant Fusion Proteins
  • Saccharomyces cerevisiae Proteins
  • Sequence Deletion
  • Trans-Activators
  • Transcription Factors
  • p300-CBP Transcription Factors