Receptor tyrosine kinases are important in cell signal transduction and proliferation. Abnormal expression of tyrosine kinases often leads to malignant transformation. C-met is a tyrosine kinase receptor and its ligand is hepatocyte growth factor (HGF). HGF/c-met plays diverse role in regulation of cell growth, shape and movement. Constitutively activated met, such as tpr-met, is a potent oncogene in vitro, but its carcinogenic role in vivo remains unclear. Our study demonstrates that expression of tpr-met leads to development of mammary tumors and other malignancies in transgenic mice, and suggests that deregulated met expression may be involved in mammary carcinogenesis.
Pubmed ID: 8675700 RIS Download
Mesh terms: Animals | Base Sequence | Female | Hyperplasia | Mammary Glands, Animal | Mammary Neoplasms, Experimental | Mice | Mice, Transgenic | Molecular Sequence Data | Proto-Oncogene Proteins c-met | Proto-Oncogenes | Receptor Protein-Tyrosine Kinases
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