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CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1.

Human immunodeficiency virus-type 1 (HIV-1) entry requires fusion cofactors on the CD4+ target cell. Fusin, a heterotrimeric GTP-binding protein (G protein)-coupled receptor, serves as a cofactor for T cell line-tropic isolates. The chemokines RANTES, MIP-1alpha, and MIP-1beta, which suppress infection by macrophage-tropic isolates, selectively inhibited cell fusion mediated by the corresponding envelope glycoproteins (Envs). Recombinant CC CKR5, a G protein-coupled receptor for these chemokines, rendered CD4-expressing nonhuman cells fusion-competent preferentially with macrophage-tropic Envs. CC CKR5 messenger RNA was detected selectively in cell types susceptible to macrophage-tropic isolates. CC CKR5 is thus a fusion cofactor for macrophage-tropic HIV-1 strains.

Pubmed ID: 8658171

Authors

  • Alkhatib G
  • Combadiere C
  • Broder CC
  • Feng Y
  • Kennedy PE
  • Murphy PM
  • Berger EA

Journal

Science (New York, N.Y.)

Publication Data

June 28, 1996

Associated Grants

None

Mesh Terms

  • 3T3 Cells
  • Animals
  • Antigens, CD4
  • Cell Fusion
  • Chemokine CCL3
  • Chemokine CCL4
  • Chemokine CCL5
  • Chemokines
  • Gene Products, env
  • Giant Cells
  • HIV-1
  • HeLa Cells
  • Humans
  • Macrophage Inflammatory Proteins
  • Macrophages
  • Membrane Fusion
  • Mice
  • Monokines
  • Receptors, CCR5
  • Receptors, Cytokine
  • Receptors, HIV
  • Recombinant Proteins
  • T-Lymphocytes
  • Tumor Cells, Cultured