Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Renal and neuronal abnormalities in mice lacking GDNF.

Nature | Jul 4, 1996

http://www.ncbi.nlm.nih.gov/pubmed/8657308

Glial cell-line derived neurotrophic factor (GDNF) is a potent survival factor for embryonic midbrain dopaminergic, spinal motor, cranial sensory, sympathetic, and hindbrain noradrenergic neurons, and is available to these cells in vivo. It is therefore considered a physiological trophic factor and a potential therapeutic agent for Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. Here we show that at postnatal day 0 (P0), GDNF-deficient mice have deficits in dorsal root ganglion, sympathetic and nodose neurons, but not in hindbrain noradrenergic or midbrain dopaminergic neurons. These mice completely lack the enteric nervous system (ENS), ureters and kidneys. Thus GDNF is important for the development and/or survival of enteric, sympathetic and sensory neurons and the renal system, but is not essential for catecholaminergic neurons in the central nervous system (CNS).

Pubmed ID: 8657308 RIS Download

Mesh terms: Animals | Brain | Cell Count | Cell Differentiation | Cell Line | Cell Survival | Digestive System | Digestive System Abnormalities | Dopamine | Gene Targeting | Glial Cell Line-Derived Neurotrophic Factor | In Situ Hybridization | Kidney | Mice | Mice, Inbred C57BL | Motor Neurons | Nerve Growth Factors | Nerve Tissue Proteins | Neurons | RNA, Messenger | Ureter

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.