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Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

SUMMARY: Disruption of the cyclin-dependent kinase-inhibitory domain of p27 enhances growth of mice. Growth is attributed to an increase in cell number, due to increased cell proliferation, most obviously in tissues that ordinarily express p27 at the highest levels. Disruption of p27 function leads to nodular hyperplasia in the intermediate lobe of the pituitary. However, increased growth occurs without an increase in the amounts of either growth hormone or IGF-I. In addition, female mice were infertile. Luteal cell differentiation is impaired, and a disordered estrus cycle is detected. These results reflect a disturbance of the hypothalamic-pituitary-ovarian axis. The phenotypes of these mice suggest that loss of p27 causes an alteration in cell proliferation that can lead to specific endocrine dysfunction.

Pubmed ID: 8646780

Authors

  • Kiyokawa H
  • Kineman RD
  • Manova-Todorova KO
  • Soares VC
  • Hoffman ES
  • Ono M
  • Khanam D
  • Hayday AC
  • Frohman LA
  • Koff A

Journal

Cell

Publication Data

May 31, 1996

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM37759
  • Agency: NIGMS NIH HHS, Id: GM52597
  • Agency: NIDDK NIH HHS, Id: NIDDK30667

Mesh Terms

  • Animals
  • Cell Cycle
  • Cell Cycle Proteins
  • Cell Division
  • Cyclin-Dependent Kinase Inhibitor p27
  • Cyclin-Dependent Kinases
  • Enzyme Inhibitors
  • Female
  • Gene Targeting
  • Growth Disorders
  • Hyperplasia
  • Hypothalamo-Hypophyseal System
  • Infertility, Female
  • Male
  • Mice
  • Mice, Knockout
  • Microtubule-Associated Proteins
  • Ovary
  • Phenotype
  • Tumor Suppressor Proteins