Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.

http://www.ncbi.nlm.nih.gov/pubmed/8642790

Mammals produce two isozymes of angiotensin-converting enzyme (ACE). Somatic ACE plays an important role in the control of blood pressure. The function of testis ACE, produced by male and germ cells, is not known. To examine the roles of these isozymes, we used targeted homologous recombination to introduce a modified ACE allele into a mouse line. Mice homozygous for this mutant allele lack both ACE isozymes and have markedly reduced blood pressures. Contrary to a previous report, we found heterozygous male mice to have normal blood pressures. Homozygous mutant mice also have severe renal disease. The renal papilla is markedly reduced, and the intrarenal arteries exhibit vascular hyperplasia associated with a perivascular inflammatory infiltrate. These animals cannot effectively concentrate urine. They also have an abnormally low urinary sodium to potassium ratio despite reduced levels of aldosterone. Homozygous mutant male mice sire significantly smaller litters than wild-type male mice; however, no defect in sperm number, morphology, or motility was detected. ACE-deficient animals demonstrate the role of this enzyme in systemic blood pressure, renal development and function, and male fertility.

Pubmed ID: 8642790 RIS Download

Mesh terms: Animals | Base Sequence | Blood Pressure | Female | Homozygote | Infertility, Male | Isoenzymes | Kidney | Kidney Concentrating Ability | Kidney Diseases | Male | Mice | Mice, Mutant Strains | Molecular Sequence Data | Peptidyl-Dipeptidase A | Polymerase Chain Reaction | Recombination, Genetic | Testis | Water Deprivation

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIDDK NIH HHS, Id: DK39777
  • Agency: NIDDK NIH HHS, Id: DK44280
  • Agency: NIDDK NIH HHS, Id: DK45215

Comparative Toxicogenomics Database (Data, Disease Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.