Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development.

The neurally expressed genes Brn-3.1 and Brn-3.2 (refs 1-6) are mammalian orthologues of the Caenorhabditis elegans unc-86 gene that constitute, with Brn-3.0 (refs 1-3,8,9), the class IV POU-domain transcription factors. Brn-3.1 and Brn-3.2 provide a means of exploring the potentially distinct biological functions of expanded gene families in neural development. The highly related members of the Brn-3 family have similar DNA-binding preferences and overlapping expression patterns in the sensory nervous system, midbrain and hindbrain, suggesting functional redundancy. Here we report that Brn-3.1 and Brn-3.2 critically modulate the terminal differentiation of distinct sensorineural cells in which they exhibit selective spatial and temporal expression patterns. Deletion of the Brn-3.2 gene causes the loss of most retinal ganglion cells, defining distinct ganglion cell populations. Mutation of Brn-3.1 results in complete deafness, owing to a failure of hair cells to appear in the inner ear, with subsequent loss of cochlear and vestibular ganglia.

Pubmed ID: 8637595


  • Erkman L
  • McEvilly RJ
  • Luo L
  • Ryan AK
  • Hooshmand F
  • O'Connell SM
  • Keithley EM
  • Rapaport DH
  • Ryan AF
  • Rosenfeld MG



Publication Data

June 13, 1996

Associated Grants

  • Agency: BLRD VA, Id: I01 BX001205

Mesh Terms

  • Animals
  • Cell Differentiation
  • DNA-Binding Proteins
  • Deafness
  • Ear, Inner
  • Embryonic and Fetal Development
  • Eye
  • Gene Deletion
  • Hair Cells, Auditory
  • Homeodomain Proteins
  • In Situ Hybridization
  • Mice
  • Multigene Family
  • Retina
  • Retinal Ganglion Cells
  • Transcription Factor Brn-3B
  • Transcription Factors