Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Hippocampal atrophy in recurrent major depression.

http://www.ncbi.nlm.nih.gov/pubmed/8632988

Hippocampal volumes of subjects with a history of major depressive episodes but currently in remission and with no known medical comorbidity were compared to matched normal controls by using volumetric magnetic resonance images. Subjects with a history of major depression had significantly smaller left and right hippocampal volumes with no differences in total cerebral volumes. The degree of hippocampal volume reduction correlated with total duration of major depression. In addition, large (diameter > or = 4.5 mm)-hippocampal low signal foci (LSF) were found within the hippocampus, and their number also correlated with the total number of days depressed. These results suggest that depression is associated with hippocampal atrophy, perhaps due to a progressive process mediated by glucocorticoid neurotoxicity.

Pubmed ID: 8632988 RIS Download

Mesh terms: Aged | Aged, 80 and over | Atrophy | Brain | Depressive Disorder | Female | Hippocampus | Humans | Hydrocortisone | Magnetic Resonance Imaging | Middle Aged | Patient Selection | Recurrence | Reference Values | Socioeconomic Factors