• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

The CBFA2 (AML1) gene encodes a DNA-binding subunit of the heterodimeric core-binding factor. The CBFA2 gene is disrupted by the (8;21), (3;21), and (12;21) chromosomal translocations associated with leukemias and myelodysplasias in humans. Mice lacking a CBF alpha 2 protein capable of binding DNA die between embryonic days 11.5 and 12.5 due to hemorrhaging in the central nervous system (CNS), at the nerve/CNS interfaces of cranial and spinal nerves, and in somitic/intersomitic regions along the presumptive spinal cord. Hemorrhaging is preceded by symmetric, bilateral necrosis in these regions. Definitive erythropoiesis and myelopoiesis do not occur in Cbfa2-deficient embryos, and disruption of one copy of the Cbfa2 gene significantly reduces the number of progenitors for erythroid and myeloid cells.

Pubmed ID: 8622955


  • Wang Q
  • Stacy T
  • Binder M
  • Marin-Padilla M
  • Sharpe AH
  • Speck NA


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

April 16, 1996

Associated Grants

  • Agency: NCI NIH HHS, Id: CA58343
  • Agency: NIAMS NIH HHS, Id: IPO30AR42689
  • Agency: NINDS NIH HHS, Id: NS-22897

Mesh Terms

  • Animals
  • Base Sequence
  • Central Nervous System Diseases
  • Core Binding Factor Alpha 2 Subunit
  • DNA Primers
  • DNA, Complementary
  • DNA-Binding Proteins
  • Erythropoiesis
  • Female
  • Fetal Death
  • Gene Targeting
  • Hematopoiesis
  • Hemorrhage
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Mutation
  • Necrosis
  • Neoplasm Proteins
  • Pregnancy
  • Proto-Oncogene Proteins
  • Proto-Oncogenes
  • Transcription Factors