Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.

http://www.ncbi.nlm.nih.gov/pubmed/8622941

Complement receptor 1 (CR1, CD35) and complement receptor 2 (CR2, CD21) have been implicated as regulators of B-cell activation. We explored the role of these receptors in the development of humoral immunity by generating CR1- and CR2-deficient mice using gene-targeting techniques. These mice have normal basal levels of IgM and of IgG isotypes. B- and T-cell development are overtly normal. Nevertheless, B-cell responses to low and high doses of a T-cell-dependent antigen are impaired with decreased titers of antigen-specific IgM and IgG isotypes. This defect is not complete because there is still partial activation of B lymphocytes during the primary immune response, with generation of splenic germinal centers and a detectable, although reduced, secondary antibody response. These data suggest that certain T-dependent antigens manifest an absolute dependence on complement receptors for the initiation of a normally robust immune response.

Pubmed ID: 8622941 RIS Download

Mesh terms: Animals | Antibody Formation | B-Lymphocytes | Erythrocytes | Gene Targeting | Immunization | Immunoglobulin G | Immunoglobulin M | Lymphocyte Activation | Mice | Mice, Knockout | Receptors, Complement 3b | Receptors, Complement 3d | Sheep | T-Lymphocytes

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIAID NIH HHS, Id: AI31105
  • Agency: NIAMS NIH HHS, Id: ARO1910-01

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.