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Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs.

Cell | Feb 9, 1996

We have identified a putative Drosophila STAT protein named Marelle that exhibits mutant phenotypes identical to mutations in the Hopscotch/JAK kinase. We show that a reduction in the amount of marelle gene activity suppresses the phenotype associated with a gain-of-function mutation in hopscotch and enhances the phenotype associated with a weak hopscotch mutation. We propose that Hopscotch activates Marelle to regulate transcription of target genes such as the pair rule gene even-skipped. Our results demonstrate the existence of an invertebrate JAK/STAT system.

Pubmed ID: 8608595 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Base Sequence | Cloning, Molecular | DNA | DNA-Binding Proteins | Drosophila | Drosophila Proteins | Female | Genes, Insect | Janus Kinases | Male | Models, Genetic | Molecular Sequence Data | Mutation | Phenotype | Protein-Tyrosine Kinases | Sequence Homology, Amino Acid | Signal Transduction | Suppression, Genetic | Trans-Activators | Transcription Factors

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