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Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs.

We have identified a putative Drosophila STAT protein named Marelle that exhibits mutant phenotypes identical to mutations in the Hopscotch/JAK kinase. We show that a reduction in the amount of marelle gene activity suppresses the phenotype associated with a gain-of-function mutation in hopscotch and enhances the phenotype associated with a weak hopscotch mutation. We propose that Hopscotch activates Marelle to regulate transcription of target genes such as the pair rule gene even-skipped. Our results demonstrate the existence of an invertebrate JAK/STAT system.

Pubmed ID: 8608595

Authors

  • Hou XS
  • Melnick MB
  • Perrimon N

Journal

Cell

Publication Data

February 9, 1996

Associated Grants

None

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA
  • DNA-Binding Proteins
  • Drosophila
  • Drosophila Proteins
  • Female
  • Genes, Insect
  • Janus Kinases
  • Male
  • Models, Genetic
  • Molecular Sequence Data
  • Mutation
  • Phenotype
  • Protein-Tyrosine Kinases
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Suppression, Genetic
  • Trans-Activators
  • Transcription Factors