• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

IRAK: a kinase associated with the interleukin-1 receptor.

The pleiotropic biological activities of interleukin-1 (IL-1) are mediated by its type I receptor (IL-1RI). When the ligand binds, IL-1RI initiates a signaling cascade that results in the activation of the transcription regulator nuclear factor kappa B (NF-kappa B). A protein kinase designated IRAK (IL-1 receptor-associated kinase) was purified, and its complementary DNA was molecularly cloned. When human embryonic kidney cells (cell line 293) over-expressing IL-1RI or HeLa cells were exposed to IL-1, IRAK rapidly associated with the IL-1RI complex and was phosphorylated. The primary amino acid sequence of IRAK shares similarity with that of Pelle, a protein kinase that is essential for the activation of a NF-kappa B homolog in Drosophila.

Pubmed ID: 8599092

Authors

  • Cao Z
  • Henzel WJ
  • Gao X

Journal

Science (New York, N.Y.)

Publication Data

February 23, 1996

Associated Grants

None

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Cell Line
  • Cloning, Molecular
  • DNA, Complementary
  • Drosophila
  • Drosophila Proteins
  • HeLa Cells
  • Humans
  • Interleukin-1
  • Interleukin-1 Receptor-Associated Kinases
  • Molecular Sequence Data
  • Phosphorylation
  • Protein Kinases
  • Protein-Serine-Threonine Kinases
  • Receptors, Interleukin-1
  • Transfection