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Interaction between Wingless and Notch signaling pathways mediated by dishevelled.

In Drosophila, the Wingless and Notch signaling pathways function in m any of the same developmental patterning events. Genetic analysis demonstrates that the dishevelled gene, which encodes a molecule previously implicated in implementation of the Winglass signal, interacts antagonistically with Notch and one of its known ligands, Delta. A direct physical interaction between Dishevelled and the Notch carboxyl terminus, distal to the cdc10/ankyrin repeats, suggests a mechanism for this interaction. It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways.

Pubmed ID: 8596950


  • Axelrod JD
  • Matsuno K
  • Artavanis-Tsakonas S
  • Perrimon N


Science (New York, N.Y.)

Publication Data

March 29, 1996

Associated Grants


Mesh Terms

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Sequence
  • Animals
  • Clone Cells
  • Drosophila
  • Drosophila Proteins
  • Genes, Insect
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Molecular Sequence Data
  • Mutation
  • Phenotype
  • Phosphoproteins
  • Proteins
  • Proto-Oncogene Proteins
  • Pupa
  • Receptors, Notch
  • Signal Transduction
  • Wing
  • Wnt1 Protein