Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Interaction between Wingless and Notch signaling pathways mediated by dishevelled.

In Drosophila, the Wingless and Notch signaling pathways function in m any of the same developmental patterning events. Genetic analysis demonstrates that the dishevelled gene, which encodes a molecule previously implicated in implementation of the Winglass signal, interacts antagonistically with Notch and one of its known ligands, Delta. A direct physical interaction between Dishevelled and the Notch carboxyl terminus, distal to the cdc10/ankyrin repeats, suggests a mechanism for this interaction. It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways.

Pubmed ID: 8596950


  • Axelrod JD
  • Matsuno K
  • Artavanis-Tsakonas S
  • Perrimon N


Science (New York, N.Y.)

Publication Data

March 29, 1996

Associated Grants


Mesh Terms

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Sequence
  • Animals
  • Clone Cells
  • Drosophila
  • Drosophila Proteins
  • Genes, Insect
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Molecular Sequence Data
  • Mutation
  • Phenotype
  • Phosphoproteins
  • Proteins
  • Proto-Oncogene Proteins
  • Pupa
  • Receptors, Notch
  • Signal Transduction
  • Wing
  • Wnt1 Protein