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Interaction between Wingless and Notch signaling pathways mediated by dishevelled.

Science (New York, N.Y.) | Mar 29, 1996

In Drosophila, the Wingless and Notch signaling pathways function in m any of the same developmental patterning events. Genetic analysis demonstrates that the dishevelled gene, which encodes a molecule previously implicated in implementation of the Winglass signal, interacts antagonistically with Notch and one of its known ligands, Delta. A direct physical interaction between Dishevelled and the Notch carboxyl terminus, distal to the cdc10/ankyrin repeats, suggests a mechanism for this interaction. It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways.

Pubmed ID: 8596950 RIS Download

Mesh terms: Adaptor Proteins, Signal Transducing | Amino Acid Sequence | Animals | Clone Cells | Dishevelled Proteins | Drosophila | Drosophila Proteins | Genes, Insect | Intracellular Signaling Peptides and Proteins | Membrane Proteins | Molecular Sequence Data | Mutation | Phenotype | Phosphoproteins | Proteins | Proto-Oncogene Proteins | Pupa | Receptors, Notch | Signal Transduction | Wings, Animal | Wnt1 Protein