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Structural brain abnormalities in first-episode mania.

Using magnetic resonance imaging (MRI), we studied brain morphometric differences between patients with first-episode mania (n = 17) and normal control subjects (n = 16). Patients were admitted for their first psychiatric hospitalization and met DSM-III-R criteria for bipolar disorder, manic or mixed. Diagnoses were made using the Structured Clinical Interview for DSM-III-R. Patients and control subjects were matched for age, gender, height, past history of substance abuse, and handedness, although control subjects had attained higher levels of education. MRI inversion recovery coronal scans were used for measurements. Volumetric measurements were obtained for cerebral hemispheres, lateral and third ventricles, caudate, thalamus, and cingulate gyrus. Patients with first-episode mania demonstrated significantly larger third-ventricular volumes, possibly increased lateral ventricular volumes, and differences in gray/white matter distribution compared with normal control subjects. The possible pathophysiological meaning of these findings is discussed.

Pubmed ID: 8329491


  • Strakowski SM
  • Wilson DR
  • Tohen M
  • Woods BT
  • Douglass AW
  • Stoll AL


Biological psychiatry

Publication Data

August 19, 1993

Associated Grants

  • Agency: NIMH NIH HHS, Id: NIMH MH31154
  • Agency: NIMH NIH HHS, Id: NIMH MH4844

Mesh Terms

  • Adolescent
  • Adult
  • Analysis of Variance
  • Bipolar Disorder
  • Brain
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales