• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Sonic hedgehog mediates the polarizing activity of the ZPA.

The zone of polarizing activity (ZPA) is a region at the posterior margin of the limb bud that induces mirror-image duplications when grafted to the anterior of a second limb. We have isolated a vertebrate gene, Sonic hedgehog, related to the Drosophila segment polarity gene hedgehog, which is expressed specifically in the ZPA and in other regions of the embryo, that is capable of polarizing limbs in grafting experiments. Retinoic acid, which can convert anterior limb bud tissue into tissue with polarizing activity, concomitantly induces Sonic hedgehog expression in the anterior limb bud. Implanting cells that express Sonic hedgehog into anterior limb buds is sufficient to cause ZPA-like limb duplications. Like the ZPA, Sonic hedgehog expression leads to the activation of Hox genes. Sonic hedgehog thus appears to function as the signal for antero-posterior patterning in the limb.

Pubmed ID: 8269518

Authors

  • Riddle RD
  • Johnson RL
  • Laufer E
  • Tabin C

Journal

Cell

Publication Data

December 31, 1993

Associated Grants

None

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chick Embryo
  • DNA Primers
  • Drosophila Proteins
  • Embryonic Induction
  • Extremities
  • Gene Expression
  • Hedgehog Proteins
  • In Situ Hybridization
  • Molecular Sequence Data
  • Morphogenesis
  • Proteins
  • RNA, Messenger
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Tretinoin