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Elements of the yeast pheromone response pathway required for filamentous growth of diploids.

Transmission of an external signal from receptors to downstream targets is often mediated by a conserved set of protein kinases that act in sequence (a kinase cascade). In haploid strains of Saccharomyces cerevisiae, a signal initiated by peptide pheromones is transmitted through this kinase cascade to a transcription factor STE12, which is required for the expression of many mating-specific genes. Here it was shown that in diploids some of the same kinases and STE12 are required for filamentous growth, but the pheromone receptors and guanosine triphosphate-binding protein are not required for filament formation. Thus, a similar kinase cascade is activated by different signals in haploids and diploids and mediates different developmental outcomes in the two cell types.

Pubmed ID: 8259520


  • Liu H
  • Styles CA
  • Fink GR


Science (New York, N.Y.)

Publication Data

December 10, 1993

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM 35010

Mesh Terms

  • Fungal Proteins
  • GTP-Binding Proteins
  • Genes, Fungal
  • Mutation
  • Peptides
  • Phenotype
  • Protein Kinases
  • Receptors, Mating Factor
  • Receptors, Peptide
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Signal Transduction
  • Transcription Factors