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A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.

Cell | May 20, 1994

http://www.ncbi.nlm.nih.gov/pubmed/8187173

Studies in adrenocortical cells have implicated the orphan nuclear receptor SF-1 in the gene regulation of the steroid hydroxylases. We used targeted disruption of the Ftz-F1 gene, which encodes SF-1, to examine its role in intact mice. Despite normal survival in utero, all Ftz-F1 null animals died by postnatal day 8; these animals lacked adrenal glands and gonads and were severely deficient in corticosterone, supporting adrenocortical insufficiency as the probable cause of death. Male and female Ftz-F1 null mice had female internal genitalia, despite complete gonadal agenesis. These studies establish that the Ftz-F1 gene is essential for sexual differentiation and formation of the primary steroidogenic tissues.

Pubmed ID: 8187173 RIS Download

Mesh terms: Adrenal Glands | Adrenocorticotropic Hormone | Animals | Animals, Newborn | Apoptosis | Base Sequence | Cell Movement | Cloning, Molecular | Corticosterone | DNA-Binding Proteins | Fallopian Tubes | Female | Fushi Tarazu Transcription Factors | Germ Cells | Gonads | Homeodomain Proteins | Male | Mice | Mice, Knockout | Molecular Sequence Data | Receptors, Cytoplasmic and Nuclear | Sex Differentiation | Steroidogenic Factor 1 | Transcription Factors

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Associated grants

  • Agency: NHLBI NIH HHS, Id: HL48460

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