Maintenance has been completed and SciCrunch services have been restored. We apologize for any inconvenience it may have caused.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Brain regions associated with acquisition and retrieval of verbal episodic memory.

It is widely held that conscious recall of past experiences involves a specific system--episodic memory. Patients with amnesia have gross impairments of episodic memory while other kinds of memory remain intact, suggesting that a separable brain system underlies episodic memory. We have used positron emission tomography (PET) to identify components of this system in normal volunteers. A dual-task interference paradigm was used to isolate brain areas associated with acquisition, and a cueing paradigm to isolate the areas concerned with retrieval from verbal episodic memory. Acquisition was associated with activity in the left prefrontal cortex and the retrosplenial area, whereas retrieval was associated with activity in right prefrontal cortex and the precuneus. Our results provide clear evidence that episodic memory involves a network of specific prefrontal and posterior structures which can be fractionated into different component processes.

Pubmed ID: 8145849

Authors

  • Shallice T
  • Fletcher P
  • Frith CD
  • Grasby P
  • Frackowiak RS
  • Dolan RJ

Journal

Nature

Publication Data

April 14, 1994

Associated Grants

None

Mesh Terms

  • Brain
  • Brain Mapping
  • Humans
  • Male
  • Memory
  • Mental Recall
  • Tomography, Emission-Computed
  • Verbal Learning