Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.

Cell | Mar 25, 1994

http://www.ncbi.nlm.nih.gov/pubmed/8137432

Brain-derived neurotrophic factor (BDNF), a neurotrophin, enhances the survival and differentiation of several classes of neurons in vitro. To determine its essential functions, we have mutated the BDNF gene. Most homozygote mutants die within 2 days after birth, but a fraction live for 2-4 weeks. These develop symptoms of nervous system dysfunction, including ataxia. The BDNF mutant homozygotes have substantially reduced numbers of cranial and spinal sensory neurons. Although their central nervous systems show no gross structural abnormalities, expression of neuropeptide Y and calcium-binding proteins is altered in many neurons, suggesting they do not function normally. In contrast with mice lacking the BDNF receptor TrkB, motor neurons appear normal in the BDNF mutant.

Pubmed ID: 8137432 RIS Download

Mesh terms: Animals | Brain | Brain-Derived Neurotrophic Factor | Calcium-Binding Proteins | Cell Division | Cell Line | Female | Male | Mice | Mice, Inbred C57BL | Mice, Mutant Strains | Motor Neurons | Mutation | Nerve Growth Factors | Nerve Tissue Proteins | Neurons, Afferent | Sequence Deletion

Research resources used in this publication

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIMH NIH HHS, Id: MH48200
  • Agency: NINDS NIH HHS, Id: P01 NS016033
  • Agency: NINDS NIH HHS, Id: P01 NS016033-17A10014

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.