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Enhanced aggressive behavior in mice lacking 5-HT1B receptor.

The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) has been associated with mood disorders such as depression, anxiety, and impulsive violence. To define the contribution of 5-HT receptor subtypes to behavior, mutant mice lacking the 5-HT1B receptor were generated by homologous recombination. These mice did not exhibit any obvious developmental or behavioral defects. However, the hyperlocomotor effect of the 5-HT1A/1B agonist RU24969 was absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors. Moreover, when confronted with an intruder, mutant mice attacked the intruder faster and more intensely than did wild-type mice, suggesting the participation of 5-HT1B receptors in aggressive behavior.

Pubmed ID: 8091214

Authors

  • Saudou F
  • Amara DA
  • Dierich A
  • LeMeur M
  • Ramboz S
  • Segu L
  • Buhot MC
  • Hen R

Journal

Science (New York, N.Y.)

Publication Data

September 23, 1994

Associated Grants

None

Mesh Terms

  • Aggression
  • Animals
  • Brain Chemistry
  • Chimera
  • Female
  • Indoles
  • Male
  • Mice
  • Motor Activity
  • Mutation
  • Pindolol
  • Receptor, Serotonin, 5-HT1B
  • Receptors, Serotonin
  • Recombination, Genetic
  • Serotonin Receptor Agonists