Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Thrombocytopenia in c-mpl-deficient mice.

Science (New York, N.Y.) | Sep 2, 1994

http://www.ncbi.nlm.nih.gov/pubmed/8073287

Thrombopoietin (TPO) is a cytokine that is involved in the regulation of platelet production. The receptor for TPO is c-Mpl. To further investigate the role and specificity of this receptor in regulating megakaryocytopoiesis, c-mpl-deficient mice were generated by gene targeting. The c-mpl-/- mice had an 85 percent decrease in their number of platelets and megakaryocytes but had normal amounts of other hematopoietic cell types. These mice also had increased concentrations of circulating TPO. These results show that c-mpl specifically regulates megakaryocytopoiesis and thrombopoiesis through activation by its ligand TPO.

Pubmed ID: 8073287 RIS Download

Mesh terms: Animals | Blood Cell Count | Blood Platelets | Genetic Vectors | Hematopoiesis | Megakaryocytes | Mice | Neoplasm Proteins | Platelet Count | Proto-Oncogene Proteins | Receptors, Cytokine | Receptors, Immunologic | Receptors, Thrombopoietin | Recombination, Genetic | Thrombocytopenia | Thrombopoietin

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.