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Isolation of a novel gene mutated in Wiskott-Aldrich syndrome.

Cell | Aug 26, 1994

Wiskott-Aldrich syndrome (WAS) is an X-linked recessive immunodeficiency characterized by eczema, thrombocytopenia, and recurrent infections. Linkage studies have placed the gene at Xp11.22-p11.23. We have isolated from this interval a novel gene, WASP, which is expressed in lymphocytes, spleen, and thymus. The gene is not expressed in two unrelated WAS patients, one of whom has a single base deletion that produces a frame shift and premature termination of translation. Two additional patients have been identified with point mutations that change the same arginine residue to either a histidine or a leucine. WASP encodes a 501 amino acid proline-rich protein that is likely to be a key regulator of lymphocyte and platelet function.

Pubmed ID: 8069912 RIS Download

Mesh terms: Amino Acid Sequence | Amino Acids | Base Sequence | Chromosome Mapping | Cloning, Molecular | DNA, Complementary | Female | Genetic Linkage | Humans | Infant | Male | Molecular Sequence Data | Organ Specificity | Pedigree | Point Mutation | Proteins | RNA, Messenger | Sequence Analysis, DNA | Sequence Deletion | Wiskott-Aldrich Syndrome | Wiskott-Aldrich Syndrome Protein | X Chromosome

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