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HNF-3 beta is essential for node and notochord formation in mouse development.

HNF-3 beta, a member of the HNF-3/fork head family of transcription factors, is expressed in the node, notochord, floor plate, and gut in mouse embryos. A null mutation of this gene leads to embryonic lethality. The primary defect of HNF-3 beta -/- embryos is an absence of organized node and notochord formation, which leads to secondary defects in dorsal-ventral patterning of the neural tube. In contrast, patterning along the anterior-posterior axis was surprisingly little affected. Although HNF-3 beta is required for node and notochord formation, some organizer activity persists in the absence of these structures. HNF-3 beta is not required for the development of definitive endoderm cells, but foregut morphogenesis is severely affected in HNF-3 beta -/- embryos.

Pubmed ID: 8069909

Authors

  • Ang SL
  • Rossant J

Journal

Cell

Publication Data

August 26, 1994

Associated Grants

None

Mesh Terms

  • Animals
  • Base Sequence
  • Central Nervous System
  • Chimera
  • Crosses, Genetic
  • DNA-Binding Proteins
  • Digestive System
  • Embryonic and Fetal Development
  • Female
  • Gastrula
  • Genes, Lethal
  • Hepatocyte Nuclear Factor 3-beta
  • Male
  • Mesoderm
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Notochord
  • Nuclear Proteins
  • Phenotype
  • Transcription Factors