HNF-3 beta is essential for node and notochord formation in mouse development.
HNF-3 beta, a member of the HNF-3/fork head family of transcription factors, is expressed in the node, notochord, floor plate, and gut in mouse embryos. A null mutation of this gene leads to embryonic lethality. The primary defect of HNF-3 beta -/- embryos is an absence of organized node and notochord formation, which leads to secondary defects in dorsal-ventral patterning of the neural tube. In contrast, patterning along the anterior-posterior axis was surprisingly little affected. Although HNF-3 beta is required for node and notochord formation, some organizer activity persists in the absence of these structures. HNF-3 beta is not required for the development of definitive endoderm cells, but foregut morphogenesis is severely affected in HNF-3 beta -/- embryos.
Pubmed ID: 8069909 RIS Download
Animals | Base Sequence | Central Nervous System | Chimera | Crosses, Genetic | DNA-Binding Proteins | Digestive System | Embryonic and Fetal Development | Female | Gastrula | Genes, Lethal | Hepatocyte Nuclear Factor 3-beta | Male | Mesoderm | Mice | Mice, Inbred C57BL | Molecular Sequence Data | Notochord | Nuclear Proteins | Phenotype | Transcription Factors