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MHC class I expression in mice lacking the proteasome subunit LMP-7.

Science (New York, N.Y.) | Aug 26, 1994

http://www.ncbi.nlm.nih.gov/pubmed/8066463

Proteasomes degrade endogenous proteins. Two subunits, LMP-2 and LMP-7, are encoded in a region of the major histocompatibility complex (MHC) that is critical for class I-restricted antigen presentation. Mice with a targeted deletion of the gene encoding LMP-7 have reduced levels of MHC class I cell-surface expression and present the endogenous antigen HY inefficiently; addition of peptides to splenocytes deficient in LMP-7 restores wild-type class I expression levels. This demonstrates the involvement of LMP-7 in the MHC class I presentation pathway and suggests that LMP-7 functions as an integral part of the peptide supply machinery.

Pubmed ID: 8066463 RIS Download

Mesh terms: ATP-Binding Cassette Transporters | Amino Acid Sequence | Animals | Antigen Presentation | Antigen-Presenting Cells | Base Sequence | Carrier Proteins | Cysteine Endopeptidases | Female | Gene Deletion | H-2 Antigens | H-Y Antigen | Lymphocytes | Male | Mice | Mice, Knockout | Molecular Sequence Data | Multienzyme Complexes | Proteasome Endopeptidase Complex | Proteins

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