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MHC class I expression in mice lacking the proteasome subunit LMP-7.

Proteasomes degrade endogenous proteins. Two subunits, LMP-2 and LMP-7, are encoded in a region of the major histocompatibility complex (MHC) that is critical for class I-restricted antigen presentation. Mice with a targeted deletion of the gene encoding LMP-7 have reduced levels of MHC class I cell-surface expression and present the endogenous antigen HY inefficiently; addition of peptides to splenocytes deficient in LMP-7 restores wild-type class I expression levels. This demonstrates the involvement of LMP-7 in the MHC class I presentation pathway and suggests that LMP-7 functions as an integral part of the peptide supply machinery.

Pubmed ID: 8066463

Authors

  • Fehling HJ
  • Swat W
  • Laplace C
  • Kühn R
  • Rajewsky K
  • Müller U
  • von Boehmer H

Journal

Science (New York, N.Y.)

Publication Data

August 26, 1994

Associated Grants

None

Mesh Terms

  • ATP-Binding Cassette Transporters
  • Amino Acid Sequence
  • Animals
  • Antigen Presentation
  • Antigen-Presenting Cells
  • Base Sequence
  • Carrier Proteins
  • Cysteine Endopeptidases
  • Female
  • Gene Deletion
  • H-2 Antigens
  • H-Y Antigen
  • Lymphocytes
  • Male
  • Mice
  • Mice, Knockout
  • Molecular Sequence Data
  • Multienzyme Complexes
  • Proteasome Endopeptidase Complex
  • Proteins