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Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog.

Interleukin-8 (IL-8) is a proinflammatory cytokine that specifically attracts and activates human neutrophils. A murine gene with a high degree of homology to the two known human IL-8 receptors was cloned and then deleted from the mouse genome by homologous recombination in embryonic stem (ES) cells. These mice, although outwardly healthy, had lymphadenopathy, resulting from an increase in B cells, and splenomegaly, resulting from an increase in metamyelocytes, band, and mature neutrophils. Thus, this receptor may participate in the expansion and development of neutrophils and B cells. This receptor was the major mediator of neutrophil migration to sites of inflammation and may provide a potential therapeutic target in inflammatory disease.

Pubmed ID: 8036519


  • Cacalano G
  • Lee J
  • Kikly K
  • Ryan AM
  • Pitts-Meek S
  • Hultgren B
  • Wood WI
  • Moore MW


Science (New York, N.Y.)

Publication Data

July 29, 1994

Associated Grants


Mesh Terms

  • Animals
  • B-Lymphocytes
  • Bone Marrow
  • Cell Movement
  • Chimera
  • Hematopoiesis, Extramedullary
  • Inflammation
  • Leukocyte Count
  • Lymph Nodes
  • Mice
  • Mice, Inbred C57BL
  • Neutrophils
  • Receptors, Interleukin
  • Receptors, Interleukin-8B
  • Recombination, Genetic
  • Spleen
  • Stem Cells