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The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway.

We show that the activities of two Ets-related transcription factors required for normal eye development in Drosophila, pointed and yan, are regulated by the Ras1/MAPK pathway. The pointed gene codes for two related proteins, and we show that one form is a constitutive activator of transcription, while the activity of the other form is stimulated by the Ras1/MAPK pathway. Mutation of the single consensus MAPK phosphorylation site in the second form abrogates this responsiveness. yan is a negative regulator of photoreceptor determination, and genetic data suggest that it acts as an antagonist of Ras1. We demonstrate that yan can repress transcription and that this repression activity is negatively regulated by the Ras1/MAPK signal, most likely through direct phosphorylation of yan by MAPK.

Pubmed ID: 8033205


  • O'Neill EM
  • Rebay I
  • Tjian R
  • Rubin GM



Publication Data

July 15, 1994

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM33135

Mesh Terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases
  • DNA-Binding Proteins
  • Drosophila
  • Drosophila Proteins
  • Extracellular Signal-Regulated MAP Kinases
  • Eye
  • Eye Proteins
  • Gene Expression Regulation
  • Genes, Insect
  • Genes, ras
  • Models, Biological
  • Morphogenesis
  • Nerve Tissue Proteins
  • Phenotype
  • Photoreceptor Cells, Invertebrate
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins p21(ras)
  • Repressor Proteins
  • Signal Transduction
  • Transcription Factors
  • Transcription, Genetic