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Naive T cells can mediate delayed-type hypersensitivity response in T cell receptor transgenic mice.

We produced transgenic mice expressing T cell receptor-alpha beta chain genes, derived from the chicken ovalbumin (OVA)-specific I-Ad-restricted CD4+CD8- T helper cell clone 7-3-7. In transgenic mice with H-2d genetic background (Tg-d mice), delayed-type hypersensitivity (DTH) was induced in the hind footpad by one inoculation with OVA without any previous sensitization, suggesting that naive T cells have the potential to be involved in DTH response. Spleen cells from nonimmunized Tg-d mice showed a strong T cell proliferative response to in vitro stimulation with OVA. Furthermore, these spleen cells produce cytokines including interleukin(IL)-2, IL-3, interferon-gamma, granulocyte/macrophage colony-stimulating factor, macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, which may play an important role in the attraction of mononuclear cells to an antigen-challenging site.

Pubmed ID: 8026513 RIS Download

Mesh terms: Animals | Base Sequence | Cell Differentiation | Cytokines | Flow Cytometry | Hypersensitivity, Delayed | Immunologic Memory | Mice | Mice, Inbred BALB C | Mice, Transgenic | Molecular Sequence Data | Polymerase Chain Reaction | Receptors, Antigen, T-Cell, alpha-beta | T-Lymphocytes