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Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.

Science (New York, N.Y.) | Jul 1, 1994

http://www.ncbi.nlm.nih.gov/pubmed/8016642

Deletion of the promoter and the first exon of the DNA polymerase beta gene (pol beta) in the mouse germ line results in a lethal phenotype. With the use of the bacteriophage-derived, site-specific recombinase Cre in a transgenic approach, the same mutation can be selectively introduced into a particular cellular compartment-in this case, T cells. The impact of the mutation on those cells can then be analyzed because the mutant animals are viable.

Pubmed ID: 8016642 RIS Download

Mesh terms: Animals | DNA Nucleotidyltransferases | DNA Polymerase I | Female | Gene Deletion | Genetic Engineering | Homozygote | Integrases | Male | Mice | Mice, Knockout | Mice, Transgenic | Mutation | Recombination, Genetic | Stem Cells | T-Lymphocytes | Transfection | Viral Proteins

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