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Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.

Deletion of the promoter and the first exon of the DNA polymerase beta gene (pol beta) in the mouse germ line results in a lethal phenotype. With the use of the bacteriophage-derived, site-specific recombinase Cre in a transgenic approach, the same mutation can be selectively introduced into a particular cellular compartment-in this case, T cells. The impact of the mutation on those cells can then be analyzed because the mutant animals are viable.

Pubmed ID: 8016642


  • Gu H
  • Marth JD
  • Orban PC
  • Mossmann H
  • Rajewsky K


Science (New York, N.Y.)

Publication Data

July 1, 1994

Associated Grants


Mesh Terms

  • Animals
  • DNA Nucleotidyltransferases
  • DNA Polymerase I
  • Female
  • Gene Deletion
  • Genetic Engineering
  • Homozygote
  • Integrases
  • Male
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Mutation
  • Recombination, Genetic
  • Stem Cells
  • T-Lymphocytes
  • Transfection
  • Viral Proteins